The efficacy of COVID-19 vaccines has recently been analyzed through a meta-analysis from August to October 2021compared to outcomes by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. At present, more than 4.6 billion persons, about 59% of the world population, on the planet have received one or more doses. Vaccination campaigns against COVID-19 began one year ago. In this manner, informing individuals, families, and communities of the characteristics of vaccines makes the risk–benefit of each of the vaccines more familiar, doubtlessly contributing to the population’s health. Nevertheless, adverse effects do not outweigh the indisputable advantages vaccines offer to humanity by preventing diseases that constitute a significant economic, social, and familial burden. However, unlike antimicrobial agents used to treat infected persons, vaccines are applied to healthy subjects to prevent infections therefore, adverse effects acquire great relevance. Vaccines represent one of the most critical advances in medicine and are the most effective method to prevent morbidity and mortality associated with infections.
Vaccines, autoimmunity, and autoimmune syndromes Rheumatologists must be alert to the development of these autoimmune syndromes, and investigate the relationship between autoimmune/inflammatory symptoms and vaccination time, and assess their therapeutic response. Fortunately, most of these autoimmune syndromes are easily controlled with steroids and other immunomodulatory medications and are short-lived. The descriptions of these autoimmune syndromes open new perspectives to the knowledge of the complex relationship between the host, its immune system, with the new vaccines and the development of new-onset autoimmune syndromes. Many of these autoimmune syndromes meet sufficient criteria for the diagnosis of Adjuvant-Induced Autoimmune Syndrome (ASIA syndrome). The exact mechanisms for the development of these autoimmune syndromes are under study, and to date, a cause-effect relationship has not been established. According to the criteria for post-vaccine adverse events established by the World Health Organization, a minority of individuals may develop adverse events, including autoimmune syndromes. Multiple studies have demonstrated the effectiveness and safety of vaccines against COVID-19 in healthy populations, in people with risk factors, in people with or without SARS-CoV-2 infection, and in immunocompromised people. To date, around 60% of the world population has been protected by vaccines against SARS-CoV-2, significantly reducing the devastating effect of the pandemic and restoring social economic activity through mass vaccination.
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